› 4edm

X-ray diffraction
2Å resolution

Crystal structure of beta-parvin CH2 domain

Released:
DOI: 10.2210/pdb4edm/pdb
PDB entry 4edm coloured by chain, front view.
PDB entry 4edm coloured by chain, side view.
PDB entry 4edm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for paxillin binding and focal adhesion targeting of β-parvin.
Stiegler AL, Draheim KM, Li X, Chayen NE, Calderwood DA, Boggon TJ
J Biol Chem 287 32566-77 (2012)
PMID: 22869380

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190756 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-parvin Chains: A, B
Molecule details ›
Chains: A, B
Length: 133 amino acids
Theoretical weight: 15.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HBI1 (Residues: 235-364; Coverage: 36%)
Gene names: CGI-56, PARVB
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

1 bound ligand:
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P212121
Unit cell:
a: 49.36Å b: 67.438Å c: 105.712Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Chapter 22: Structural and signaling functions of integrins.
Kadry et al. (2020)
2 more

1 mention without citation

Structural basis for paxillin binding and focal adhesion targeting of β-parvin.
Stiegler et al. (2012)