› 4efd

X-ray diffraction
2.45Å resolution

Crystal Structure of an M17 aminopeptidase from Trypanosoma Brucei, Tb427tmp.02.4440

Released:
DOI: 10.2210/pdb4efd/pdb
PDB entry 4efd coloured by chain, front view.
PDB entry 4efd coloured by chain, side view.
PDB entry 4efd coloured by chain, top view.
Source organism: Trypanosoma brucei brucei TREU927
Entry authors: Wernimont AK, Osman KT, Loppnau P, Arrowsmith CH, Edwards AM, Bountra C, Hui R, Lin YH, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174341 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosol aminopeptidase domain-containing protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 522 amino acids
Theoretical weight: 55.48 KDa
Source organism: Trypanosoma brucei brucei TREU927
Expression system: Escherichia coli
UniProt:
  • Canonical: Q385B0 (Residues: 1-521; Coverage: 100%)
Gene name: Tb11.02.4440
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand SO4 12 x SO4
Ligand MN 8 x MN
Ligand GOL 8 x GOL
Ligand UNX 6 x UNX
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 161.916Å b: 161.74Å c: 176.315Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.253
Expression system: Escherichia coli

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