› 4ekw

X-ray diffraction
3.21Å resolution

Crystal structure of the NavAb voltage-gated sodium channel (wild-type, 3.2 A)

Released:
DOI: 10.2210/pdb4ekw/pdb
PDB entry 4ekw coloured by chain, front view.
PDB entry 4ekw coloured by chain, side view.
PDB entry 4ekw coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states.
Payandeh J, Gamal El-Din TM, Scheuer T, Zheng N, Catterall WA
Nature 486 135-9 (2012)
PMID: 22678296

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 285 amino acids
Theoretical weight: 33.72 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PX4 5 x PX4
Ligand PO4 4 x PO4
1 modified residue:
Ligand MSE 52 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P42
Unit cell:
a: 125.856Å b: 125.856Å c: 192.641Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.309 0.308 0.322
Expression system: Trichoplusia ni

Quick links

Citations

80 review citations

Neurological perspectives on voltage-gated sodium channels.
Eijkelkamp et al. (2012)
79 more

44 mentions without citation

Structure of potassium channels.
Kuang et al. (2015)
43 more