› 4f2i

X-ray diffraction
1.67Å resolution

Crystal structure of glutaredoxin-like NrdH from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb4f2i/pdb
PDB entry 4f2i coloured by chain, front view.
PDB entry 4f2i coloured by chain, side view.
PDB entry 4f2i coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
The crystal structure of Mycobacterium tuberculosis NrdH at 0.87 Å suggests a possible mode of its activity.
Phulera S, Mande SC
Biochemistry 52 4056-65 (2013)
PMID: 23675692

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-like protein NrdH Chain: A
Molecule details ›
Chain: A
Length: 84 amino acids
Theoretical weight: 9.13 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: I6YB06 (Residues: 2-79; Coverage: 99%)
Gene names: Rv3053c, nrdH
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand NO3 2 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: P21212
Unit cell:
a: 52Å b: 48.18Å c: 26.23Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.172 0.212
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

Streptococcus sanguinis class Ib ribonucleotide reductase: high activity with both iron and manganese cofactors and structural insights.
Makhlynets et al. (2014)
8 more

2 mentions without citation

Two-dimensional crystal engineering using halogen and hydrogen bonds: towards structural landscapes.
Mukherjee et al. (2017)
1 more