› 4f57

X-ray diffraction
1.7Å resolution

Fab structure of a neutralizing antibody L1 from an early subtype A HIV-1 infected patient

Released:
DOI: 10.2210/pdb4f57/pdb
PDB entry 4f57 coloured by chain, front view.
PDB entry 4f57 coloured by chain, side view.
PDB entry 4f57 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth.
Murphy MK, Yue L, Pan R, Boliar S, Sethi A, Tian J, Pfafferot K, Karita E, Allen SA, Cormier E, Goepfert PA, Borrow P, Robinson JE, Gnanakaran S, Hunter E, Kong XP, Derdeyn CA
PLoS Pathog 9 e1003173 (2013)
PMID: 23468623

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213461 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Light chain of Fab of a neutralizing antibody L1 Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 22.48 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
Heavy chain of Fab of a neutralizing antibody L1 Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.45 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2
Unit cell:
a: 152.101Å b: 57.463Å c: 60.038Å
α: 90° β: 112.78° γ: 90°
R-values:
R R work R free
0.188 0.186 0.209

Quick links

Citations

7 review citations

Deconstructing the Antiviral Neutralizing-Antibody Response: Implications for Vaccine Development and Immunity.
VanBlargan et al. (2016)
6 more

2 mentions without citation

Viral escape from neutralizing antibodies in early subtype A HIV-1 infection drives an increase in autologous neutralization breadth.
Murphy et al. (2013)
1 more