› 4f8k

X-ray diffraction
1.7Å resolution

Molecular analysis of the interaction between the prostacyclin receptor and the first PDZ domain of PDZK1

Released:
DOI: 10.2210/pdb4f8k/pdb
PDB entry 4f8k coloured by chain, front view.
PDB entry 4f8k coloured by chain, side view.
PDB entry 4f8k coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1.
Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O
PLoS One 8 e53819 (2013)
PMID: 23457445

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155006 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Prostacyclin receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.02 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JIL4 (Residues: 7-106; Coverage: 19%)
  • Canonical: P43252 (Residues: 409-415; Coverage: 2%)
Gene names: Cap70, Nherf3, Pdzk1, Ptgir
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 39.271Å b: 68.477Å c: 40.124Å
α: 90° β: 91.75° γ: 90°
R-values:
R R work R free
0.186 0.184 0.219
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Prostacyclin analogue beraprost inhibits cardiac fibroblast proliferation depending on prostacyclin receptor activation through a TGF β-Smad signal pathway.
Chen et al. (2014)
3 more

3 mentions without citation

Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives.
Khalid et al. (2018)
2 more