› 4f8q

X-ray diffraction
2.38Å resolution

Crystal Structure of the Human BTN3A2 Ectodomain

Released:
DOI: 10.2210/pdb4f8q/pdb
PDB entry 4f8q coloured by chain, front view.
PDB entry 4f8q coloured by chain, side view.
PDB entry 4f8q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ
J Biol Chem 287 32780-90 (2012)
PMID: 22846996

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A2 Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P78410 (Residues: 30-239; Coverage: 69%)
Gene names: BT3.2, BTF3, BTF4, BTN3A2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Unit cell:
a: 33.001Å b: 77.579Å c: 100.966Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.232 0.268
Expression system: Trichoplusia ni

Quick links

Citations

37 review citations

Six-of-the-best: unique contributions of γδ T cells to immunology.
Vantourout et al. (2013)
36 more

4 mentions without citation

Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells.
Wang et al. (2013)
3 more