› 4f8t

X-ray diffraction
2.38Å resolution

Crystal Structure of the Human BTN3A3 Ectodomain

Released:
DOI: 10.2210/pdb4f8t/pdb
PDB entry 4f8t coloured by chain, front view.
PDB entry 4f8t coloured by chain, side view.
PDB entry 4f8t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies.
Palakodeti A, Sandstrom A, Sundaresan L, Harly C, Nedellec S, Olive D, Scotet E, Bonneville M, Adams EJ
J Biol Chem 287 32780-90 (2012)
PMID: 22846996

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Butyrophilin subfamily 3 member A3 Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 24.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O00478 (Residues: 30-246; Coverage: 39%)
Gene names: BTF3, BTN3A3
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Unit cell:
a: 39.841Å b: 78.43Å c: 98.412Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.245
Expression system: Trichoplusia ni

Quick links

Citations

37 review citations

Six-of-the-best: unique contributions of γδ T cells to immunology.
Vantourout et al. (2013)
36 more

5 mentions without citation

Butyrophilin 3A1 plays an essential role in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells.
Wang et al. (2013)
4 more