› 4fn0

X-ray diffraction
3.35Å resolution

Crystal structure of mouse nectin-2 extracellular fragment D1-D2, 2nd crystal form

Released:
DOI: 10.2210/pdb4fn0/pdb
PDB entry 4fn0 coloured by chain, front view.
PDB entry 4fn0 coloured by chain, side view.
PDB entry 4fn0 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Nectin ectodomain structures reveal a canonical adhesive interface.
Harrison OJ, Vendome J, Brasch J, Jin X, Hong S, Katsamba PS, Ahlsen G, Troyanovsky RB, Troyanovsky SM, Honig B, Shapiro L
Nat Struct Mol Biol 19 906-15 (2012)
PMID: 22902367

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Nectin-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 225 amino acids
Theoretical weight: 24.92 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P32507 (Residues: 32-250; Coverage: 44%)
Gene names: Mph, Nectin2, Pvr, Pvrl2, Pvs
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P3121
Unit cell:
a: 117.022Å b: 117.022Å c: 158.467Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.247 0.293
Expression system: Homo sapiens

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Citations

17 review citations

Mechanobiology of collective cell behaviours.
Ladoux et al. (2017)
16 more