› 4fn9

X-ray diffraction
3Å resolution

X-ray Crystal structure of the Ancestral 3-keto steroid receptor - Progesterone complex

Released:
DOI: 10.2210/pdb4fn9/pdb
PDB entry 4fn9 coloured by chain, front view.
PDB entry 4fn9 coloured by chain, side view.
PDB entry 4fn9 coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Evolution of minimal specificity and promiscuity in steroid hormone receptors.
Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW
PLoS Genet 8 e1003072 (2012)
PMID: 23166518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164470 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 254 amino acids
Theoretical weight: 29.2 KDa
Source organism: Unidentified
Expression system: Escherichia coli
Structure domains: Retinoid X Receptor

Ligands and Environments

5 bound ligands:
Ligand STR 2 x STR
Ligand GOL 2 x GOL
Ligand MES 2 x MES
Ligand CPS 2 x CPS
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P212121
Unit cell:
a: 53.472Å b: 112.108Å c: 132.846Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.203 0.26
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Weikum et al. (2017)
21 more

5 mentions without citation

Evolution of minimal specificity and promiscuity in steroid hormone receptors.
Eick et al. (2012)
4 more