› 4fne

X-ray diffraction
2.78Å resolution

X-ray Crystal structure of the Ancestral 3-keto steroid receptor - DOC complex

Released:
DOI: 10.2210/pdb4fne/pdb
PDB entry 4fne coloured by chain, front view.
PDB entry 4fne coloured by chain, side view.
PDB entry 4fne coloured by chain, top view.
Source organism: Unidentified
Primary publication:
Evolution of minimal specificity and promiscuity in steroid hormone receptors.
Eick GN, Colucci JK, Harms MJ, Ortlund EA, Thornton JW
PLoS Genet 8 e1003072 (2012)
PMID: 23166518

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164472 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Steroid receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 29.2 KDa
Source organism: Unidentified
Expression system: Escherichia coli
Structure domains: Retinoid X Receptor

Ligands and Environments

5 bound ligands:
Ligand 1CA 1 x 1CA
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
Ligand MES 1 x MES
Ligand CPS 1 x CPS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 52.795Å b: 111.618Å c: 130.765Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.207 0.28
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.
Weikum et al. (2017)
21 more

1 mention without citation

Evolution of minimal specificity and promiscuity in steroid hormone receptors.
Eick et al. (2012)