› 4fq2

X-ray diffraction
1.9Å resolution

Crystal Structure of 10-1074 Fab

Released:
DOI: 10.2210/pdb4fq2/pdb
PDB entry 4fq2 coloured by chain, front view.
PDB entry 4fq2 coloured by chain, side view.
PDB entry 4fq2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ
Proc Natl Acad Sci U S A 109 E3268-77 (2012)
PMID: 23115339

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213465 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 244 amino acids
Theoretical weight: 26.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand 144 1 x 144
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P21
Unit cell:
a: 61.383Å b: 40.261Å c: 84.46Å
α: 90° β: 95.39° γ: 90°
R-values:
R R work R free
0.188 0.187 0.223
Expression system: Homo sapiens

Quick links

Citations

84 review citations

Antibodies in HIV-1 vaccine development and therapy.
Klein et al. (2013)
83 more

9 mentions without citation

Antiviral Therapy by HIV-1 Broadly Neutralizing and Inhibitory Antibodies.
Zhang et al. (2016)
8 more