› 4fqt

X-ray diffraction
2.2Å resolution

Structure of AgamOBP1 Bound to 6-methyl-5-hepten-2-one

Released:
DOI: 10.2210/pdb4fqt/pdb
PDB entry 4fqt coloured by chain, front view.
PDB entry 4fqt coloured by chain, side view.
PDB entry 4fqt coloured by chain, top view.
Source organism: Anopheles gambiae str. PEST
Primary publication:
Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET).
Murphy EJ, Booth JC, Davrazou F, Port AM, Jones DN
J Biol Chem 288 4475-85 (2013)
PMID: 23261834

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164473 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Anopheles Gambiae Odorant Binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.55 KDa
Source organism: Anopheles gambiae str. PEST
Expression system: Escherichia coli
Structure domains: Pheromone/general odorant binding protein domain

Ligands and Environments

2 bound ligands:
Ligand 0VT 2 x 0VT
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 32.769Å b: 68.993Å c: 64.552Å
α: 90° β: 104.71° γ: 90°
R-values:
R R work R free
0.188 0.185 0.239
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Olfaction in Anopheles mosquitoes.
Konopka et al. (2021)
3 more

4 mentions without citation

Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET).
Murphy et al. (2013)
3 more