› 4fr4

X-ray diffraction
2.29Å resolution

Crystal structure of human serine/threonine-protein kinase 32A (YANK1)

Released:
DOI: 10.2210/pdb4fr4/pdb
PDB entry 4fr4 coloured by chain, front view.
PDB entry 4fr4 coloured by chain, side view.
PDB entry 4fr4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Elkins JM, Krojer T, Mahajan P, Goubin S, Szklarz M, Tumber A, Wang J, Savitsky P, Shrestha B, Daga N, Picaud S, Fedorov O, Allerston CK, Latwiel SVA, Vollmar M, Canning P, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 32A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 384 amino acids
Theoretical weight: 45.16 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WU08 (Residues: 9-390; Coverage: 97%)
Gene names: STK32A, YANK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand STU 6 x STU
Ligand EDO 8 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P32
Unit cell:
a: 154.11Å b: 154.11Å c: 112.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.244
Expression system: Spodoptera frugiperda

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