Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
2A proteinase (preferred)
PDBe Complex ID:
PDB-CPX-109085 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2A proteinase
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 16.71 KDa
Source organism: Enterovirus A71
Expression system: Escherichia coli
UniProt:
Structure domains: Trypsin-like serine proteases
Length: 152 amino acids
Theoretical weight: 16.71 KDa
Source organism: Enterovirus A71
Expression system: Escherichia coli
UniProt:
- Canonical:
A9XG43 (Residues: 863-1012; Coverage: 7%)
Structure domains: Trypsin-like serine proteases
