Function and Biology Details
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- DNA-directed DNA polymerase, family B
- DNA polymerase, palm domain superfamily
- DNA polymerase family B, thumb domain
- DNA-directed DNA polymerase, family B, conserved site
- DNA polymerase alpha catalytic subunit, catalytic domain
- DNA/RNA polymerase superfamily
- DNA-directed DNA polymerase, family B, multifunctional domain
- Ribonuclease H superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117516 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
1 distinct RNA molecule
1 distinct DNA molecule
1 distinct RNA molecule
Macromolecules (3 distinct):
DNA polymerase alpha catalytic subunit A
Molecule details ›
Chains: A, B
Length: 910 amino acids
Theoretical weight: 103.53 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Structure domains:
Length: 910 amino acids
Theoretical weight: 103.53 KDa
Source organism: Saccharomyces cerevisiae S288C
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P13382 (Residues: 349-1258; Coverage: 62%)
Sequence domains:
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID14-1
Spacegroup:
P1
Expression systems:
- Escherichia coli BL21(DE3)
- Not provided
