4fz1

X-ray diffraction
3.36Å resolution

Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-158031 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acid-sensing ion channel 1 Chain: A
Molecule details ›
Chain: A
Length: 450 amino acids
Theoretical weight: 51.33 KDa
Source organism: Gallus gallus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q1XA76 (Residues: 14-463; Coverage: 85%)
Gene names: ACCN2, ASIC1
Sequence domains: Amiloride-sensitive sodium channel
Structure domains:
Psalmotoxin-1 Chain: D
Molecule details ›
Chain: D
Length: 40 amino acids
Theoretical weight: 4.71 KDa
Source organism: Psalmopoeus cambridgei
Expression system: Not provided
UniProt:
  • Canonical: P60514 (Residues: 1-40; Coverage: 100%)

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: R3
Unit cell:
a: 131.52Å b: 131.52Å c: 129.92Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.223 0.216 0.281
Expression systems:
  • Spodoptera frugiperda
  • Not provided