› 4g0h

X-ray diffraction
3.6Å resolution

Crystal structure of the N-terminal domain of Helicobacter pylori CagA protein

Released:
DOI: 10.2210/pdb4g0h/pdb
PDB entry 4g0h coloured by chain, front view.
PDB entry 4g0h coloured by chain, side view.
PDB entry 4g0h coloured by chain, top view.
Source organism: Helicobacter pylori 26695
Primary publication:
Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin.
Kaplan-Türköz B, Jiménez-Soto LF, Dian C, Ertl C, Remaut H, Louche A, Tosi T, Haas R, Terradot L
Proc Natl Acad Sci U S A 109 14640-5 (2012)
PMID: 22908298

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157374 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytotoxicity-associated immunodominant antigen Chain: A
Molecule details ›
Chain: A
Length: 916 amino acids
Theoretical weight: 103.01 KDa
Source organism: Helicobacter pylori 26695
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P55980 (Residues: 1-884; Coverage: 75%)
Gene names: HP_0547, cag26, cagA, cai
Sequence domains: CagA protein
Structure domains: CagA exotoxin domain III

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P41212
Unit cell:
a: 97.83Å b: 97.83Å c: 245.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.329 0.329 0.341
Expression system: Escherichia coli BL21

Quick links

Citations

33 review citations

Helicobacter pylori-induced gastric inflammation and gastric cancer.
Wang et al. (2014)
32 more