› 4g31

X-ray diffraction
2.28Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192755 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 2-alpha kinase 3 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZJ5 (Residues: 588-1093; Coverage: 27%)
Gene names: EIF2AK3, PEK, PERK
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand 0WH 1 x 0WH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P6122
Unit cell:
a: 101.119Å b: 101.119Å c: 158.831Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.204 0.242
Expression system: Escherichia coli

Quick links

Citations

115 review citations

The integrated stress response.
Pakos-Zebrucka et al. (2016)
114 more

7 mentions without citation

Druggable sensors of the unfolded protein response.
Maly et al. (2014)
6 more