4g5z

X-ray diffraction
1.83Å resolution

Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-213472 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
canakinumab antibody fragment heavy chain Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
canakinumab antibody fragment light chain Chain: L
Molecule details ›
Chain: L
Length: 212 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 81.216Å b: 54.585Å c: 94.088Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.222
Expression system: Not provided