4ge2

X-ray diffraction
1.8Å resolution

Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
PDBe Complex ID:
PDB-CPX-155050 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 314 amino acids
Theoretical weight: 36.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P43378 (Residues: 277-582; Coverage: 52%)
Gene name: PTPN9
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 39.982Å b: 57.747Å c: 66.544Å
α: 77.33° β: 78.28° γ: 80.27°
R-values:
R R work R free
0.188 0.188 0.225
Expression system: Escherichia coli BL21(DE3)