› 4gf2

X-ray diffraction
2.4Å resolution

Crystal structure of Plasmodium falciparum Erythrocyte Binding Antigen 140 (PfEBA-140/BAEBL)

Released:
DOI: 10.2210/pdb4gf2/pdb
PDB entry 4gf2 coloured by chain, front view.
PDB entry 4gf2 coloured by chain, side view.
PDB entry 4gf2 coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion.
Lin DH, Malpede BM, Batchelor JD, Tolia NH
J Biol Chem 287 36830-6 (2012)
PMID: 22989878

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Erythrocyte binding antigen 140 Chain: A
Molecule details ›
Chain: A
Length: 615 amino acids
Theoretical weight: 73.45 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WS31 (Residues: 141-755; Coverage: 51%)
Sequence domains: Duffy binding domain
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand GOL 15 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21
Unit cell:
a: 65.42Å b: 76.48Å c: 82.34Å
α: 90° β: 96.8° γ: 90°
R-values:
R R work R free
0.202 0.2 0.237
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Sequence variation and structural conservation allows development of novel function and immune evasion in parasite surface protein families.
Higgins et al. (2014)
9 more

6 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
5 more