› 4gfv

X-ray diffraction
2.1Å resolution

PTPN18 in complex with HER2-pY1196 phosphor-peptides

Released:
DOI: 10.2210/pdb4gfv/pdb
PDB entry 4gfv coloured by chain, front view.
PDB entry 4gfv coloured by chain, side view.
PDB entry 4gfv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wang HM, Yang F, Du YJ, Yang DX, Zhang Y, Yu X, Sun JP

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164505 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 18 Chains: A, B
Molecule details ›
Chains: A, B
Length: 297 amino acids
Theoretical weight: 33.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q99952 (Residues: 6-300; Coverage: 64%)
Gene names: BDP1, PTPN18
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily
HER2-pY1196 phosphor-peptide Chains: E, F
Molecule details ›
Chains: E, F
Length: 6 amino acids
Theoretical weight: 799 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PTR 2 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U, BSRF BEAMLINE 3W1A
Spacegroup: P212121
Unit cell:
a: 74.348Å b: 91.341Å c: 92.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.246 0.293
Expression systems:
  • Escherichia coli BL21
  • Not provided

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