› 4giw

X-ray diffraction
2Å resolution

Crystal structure of the RUN domain of human NESCA

Released:
DOI: 10.2210/pdb4giw/pdb
PDB entry 4giw coloured by chain, front view.
PDB entry 4giw coloured by chain, side view.
PDB entry 4giw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure and functional implication of the RUN domain of human NESCA.
Sun Q, Han C, Liu L, Wang Y, Deng H, Bai L, Jiang T
Protein Cell 3 609-17 (2012)
PMID: 22821014

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189765 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AP-4 complex accessory subunit RUSC1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 198 amino acids
Theoretical weight: 21.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BVN2 (Residues: 477-666; Coverage: 21%)
  • Best match: Q9BVN2-4 (Residues: 477-621)
Gene names: NESCA, RUSC1
Sequence domains: RUN domain
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 39.116Å b: 94.201Å c: 44.602Å
α: 90° β: 99.54° γ: 90°
R-values:
R R work R free
0.205 0.204 0.212
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein.
Zhou et al. (2023)
1 more

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more