› 4gm2

X-ray diffraction
2.8Å resolution

The crystal structure of a peptidase from plasmodium falciparum

Released:
DOI: 10.2210/pdb4gm2/pdb
PDB entry 4gm2 coloured by chain, front view.
PDB entry 4gm2 coloured by chain, side view.
PDB entry 4gm2 coloured by chain, top view.
Source organism: Plasmodium falciparum 3D7
Primary publication:
Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.
El Bakkouri M, Rathore S, Calmettes C, Wernimont AK, Liu K, Sinha D, Asad M, Jung P, Hui R, Mohmmed A, Houry WA
J Biol Chem 288 1022-31 (2013)
PMID: 23192353

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184814 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent Clp protease proteolytic subunit Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 205 amino acids
Theoretical weight: 23.43 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IL98 (Residues: 61-244; Coverage: 81%)
Gene name: PF3D7_1436800
Sequence domains: Clp protease
Structure domains: 2-enoyl-CoA Hydratase; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 182.898Å b: 102.162Å c: 96.414Å
α: 90° β: 114.53° γ: 90°
R-values:
R R work R free
0.201 0.199 0.229
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Pseudoproteases: mechanisms and function.
Reynolds et al. (2015)
3 more

2 mentions without citation

Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.
El Bakkouri et al. (2013)
1 more