› 4gn1

X-ray diffraction
2.4Å resolution

Crystal Structure of the RA and PH domains of Lamellipodin

Released:
DOI: 10.2210/pdb4gn1/pdb
PDB entry 4gn1 coloured by chain, front view.
PDB entry 4gn1 coloured by chain, side view.
PDB entry 4gn1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Lamellipodin implicates diverse functions in actin polymerization and Ras signaling.
Chang YC, Zhang H, Brennan ML, Wu J
Protein Cell 4 211-9 (2013)
PMID: 23483482

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-associated and pleckstrin homology domains-containing protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 255 amino acids
Theoretical weight: 30.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q70E73 (Residues: 266-520; Coverage: 20%)
Gene names: ALS2CR18, ALS2CR9, KIAA1681, LPD, PREL2, RAPH1, RMO1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MLI 4 x MLI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 75.34Å b: 93.465Å c: 80.72Å
α: 90° β: 104.91° γ: 90°
R-values:
R R work R free
0.314 0.253 0.303
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling.
Li et al. (2015)
14 other articles

2 mentions without citation

Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
Cho et al. (2021)
1 more