› 4go1

X-ray diffraction
3Å resolution

Crystal Structure of full length transcription repressor LsrR from E. coli.

Released:
DOI: 10.2210/pdb4go1/pdb
PDB entry 4go1 coloured by chain, front view.
PDB entry 4go1 coloured by chain, side view.
PDB entry 4go1 coloured by chain, top view.
Source organism: Escherichia coli K-12
Primary publication:
Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli.
Wu M, Tao Y, Liu X, Zang J
J Biol Chem 288 15878-87 (2013)
PMID: 23589368

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160057 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulator LsrR Chains: A, B
Molecule details ›
Chains: A, B
Length: 325 amino acids
Theoretical weight: 34.9 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P76141 (Residues: 1-317; Coverage: 100%)
Gene names: JW1505, b1512, lsrR, ydeW
Sequence domains: Putative sugar-binding domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I222
Unit cell:
a: 79.702Å b: 113.866Å c: 185.271Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.216 0.268
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Mechanisms of Inhibition of Quorum Sensing as an Alternative for the Control of E. coli and Salmonella.
Escobar-Muciño et al. (2022)
7 other articles

1 mention without citation

Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli.
Wu et al. (2013)