4gsr

X-ray diffraction
1.79Å resolution

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L,D-transpeptidase 2 Chain: A
Molecule details ›
Chain: A
Length: 287 amino acids
Theoretical weight: 31.28 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: O53223 (Residues: 131-408; Coverage: 74%)
Gene names: MT2594, V735_02606, ldtB
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: C2
Unit cell:
a: 135.661Å b: 58.449Å c: 40.964Å
α: 90° β: 94.28° γ: 90°
R-values:
R R work R free
0.196 0.195 0.226
Expression system: Escherichia coli