› 4gv5

X-ray diffraction
1.7Å resolution

X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus

Released:
DOI: 10.2210/pdb4gv5/pdb
PDB entry 4gv5 coloured by chain, front view.
PDB entry 4gv5 coloured by chain, side view.
PDB entry 4gv5 coloured by chain, top view.
Source organism: Crotalus durissus terrificus
Primary publication:
Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.
Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C
Acta Crystallogr D Biol Crystallogr 69 1958-64 (2013)
PMID: 24100315

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-192951 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Crotamine Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 42 amino acids
Theoretical weight: 4.9 KDa
Source organism: Crotalus durissus terrificus
UniProt:
  • Canonical: Q9PWF3 (Residues: 23-64; Coverage: 98%)
Gene names: CRO2, CRT-P1
Sequence domains: Myotoxin, crotamine
Structure domains: Anthopleurin-A

Ligands and Environments

3 bound ligands:
Ligand SCN 4 x SCN
Ligand GOL 4 x GOL
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PETRA III, EMBL c/o DESY BEAMLINE P14 (MX2)
Spacegroup: I212121
Unit cell:
a: 66.922Å b: 74.33Å c: 80.199Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.167 0.225

Quick links

Citations

3 review citations

The chemistry of snake venom and its medicinal potential.
Oliveira et al. (2022)
2 more

11 mentions without citation

Membrane Active Peptides and Their Biophysical Characterization.
Avci et al. (2018)
10 more