› 4gvp

X-ray diffraction
2.03Å resolution

Crystal Structure of the Response Regulator Protein VraR from Staphylococcus aureus

Released:
DOI: 10.2210/pdb4gvp/pdb
PDB entry 4gvp coloured by chain, front view.
PDB entry 4gvp coloured by chain, side view.
PDB entry 4gvp coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus Mu50
Primary publication:
Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation.
Leonard PG, Golemi-Kotra D, Stock AM
Proc Natl Acad Sci U S A 110 8525-30 (2013)
PMID: 23650349

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Response regulator protein VraR Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 208 amino acids
Theoretical weight: 23.46 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7A2Q1 (Residues: 2-209; Coverage: 100%)
Gene names: SAV1884, vraR
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 78.149Å b: 103.804Å c: 114.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.172 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Molecular Mechanisms of Two-Component Signal Transduction.
Zschiedrich et al. (2016)
3 more

9 mentions without citation

Towards the computational design of protein post-translational regulation.
Strumillo et al. (2015)
8 more