› 4gxv

X-ray diffraction
1.45Å resolution

Crystal structure of anti-influenza virus antibody 1F1

Released:
DOI: 10.2210/pdb4gxv/pdb
PDB entry 4gxv coloured by chain, front view.
PDB entry 4gxv coloured by chain, side view.
PDB entry 4gxv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses.
Tsibane T, Ekiert DC, Krause JC, Martinez O, Crowe JE, Wilson IA, Basler CF
PLoS Pathog 8 e1003067 (2012)
PMID: 23236279

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213482 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Antibody 1F1, heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 231 amino acids
Theoretical weight: 24.91 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antibody 1F1, light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 217 amino acids
Theoretical weight: 22.79 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 4 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 51.789Å b: 99.461Å c: 175.095Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.181 0.207
Expression system: Homo sapiens

Quick links

Citations

18 review citations

From Original Antigenic Sin to the Universal Influenza Virus Vaccine.
Henry et al. (2018)
17 more

6 mentions without citation

Updates to the Integrated Protein-Protein Interaction Benchmarks: Docking Benchmark Version 5 and Affinity Benchmark Version 2.
Vreven et al. (2015)
5 more