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› 4gxw

X-ray diffraction
1.3Å resolution

Crystal structure of a cog1816 amidohydrolase (target EFI-505188) from Burkhoderia ambifaria, with bound Zn

Released:
DOI: 10.2210/pdb4gxw/pdb
Model geometry
Fit model/data
PDB entry 4gxw coloured by chain, front view.
PDB entry 4gxw coloured by chain, side view.
PDB entry 4gxw coloured by chain, top view.
Source organism: Burkholderia ambifaria AMMD
Entry authors: Vetting MW, Goble AM, Morisco LL, Wasserman SR, Sojitra S, Imker HJ, Raushel FM, Gerlt JA, Almo SC, Enzyme Function Initiative (EFI)

Function and Biology Details

Reaction catalysed: 
(1) adenosine + H2O + H(+) = inosine + NH4(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine deaminase domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 380 amino acids
Theoretical weight: 42.7 KDa
Source organism: Burkholderia ambifaria AMMD
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q0B6Q2 (Residues: 2-366; Coverage: 100%)
Gene name: Bamb_4621
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 73.058Å b: 66.223Å c: 75.432Å
α: 90° β: 93.64° γ: 90°
R-values:
R R work R free
0.161 0.16 0.181
Expression system: Escherichia coli BL21(DE3)

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