Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA-directed RNA polymerase, insert domain superfamily
- DNA-directed RNA polymerase, RpoA/D/Rpb3-type
- RNA polymerase, RBP11-like subunit
- DNA-directed RNA polymerase, alpha subunit
- RNA polymerase, subunit omega/Rpo6/RPB6
- RPB6/omega subunit-like superfamily
- DNA-directed RNA polymerase, omega subunit
- RNA polymerase Rpb1, domain 5
25 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
DNA-directed RNA polymerase and RNA and DNA (preferred)
PDBe Complex ID:
PDB-CPX-117571 (preferred)
Entry contents:
4 distinct polypeptide molecules
2 distinct DNA molecules
1 distinct RNA molecule
2 distinct DNA molecules
1 distinct RNA molecule
Macromolecules (7 distinct):
DNA-directed RNA polymerase subunit alpha
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.06 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
Sequence domains:
Length: 315 amino acids
Theoretical weight: 35.06 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
- Canonical:
Q5SHR6 (Residues: 1-315; Coverage: 100%)
Sequence domains:
- RNA polymerase Rpb3/Rpb11 dimerisation domain
- RNA polymerase Rpb3/RpoA insert domain
- Bacterial RNA polymerase, alpha chain C terminal domain
DNA-directed RNA polymerase subunit beta
Molecule details ›
Chain: C
Length: 1119 amino acids
Theoretical weight: 125.44 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
Sequence domains:
Length: 1119 amino acids
Theoretical weight: 125.44 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
- Canonical: Q8RQE9 (Residues: 1-1119; Coverage: 100%)
Sequence domains:
- RNA polymerase beta subunit
- RNA polymerase Rpb2, domain 2
- RNA polymerase Rpb2, domain 3
- RNA polymerase beta subunit external 1 domain
- RNA polymerase Rpb2, domain 6
- RNA polymerase Rpb2, domain 7
DNA-directed RNA polymerase subunit beta'
Molecule details ›
Chain: D
Length: 1534 amino acids
Theoretical weight: 172.38 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
Sequence domains:
Length: 1534 amino acids
Theoretical weight: 172.38 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
- Canonical: Q8RQE8 (Residues: 1-1524; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit omega
Molecule details ›
Chain: E
Length: 99 amino acids
Theoretical weight: 11.53 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
Sequence domains: RNA polymerase Rpb6
Structure domains: Eukaryotic RPB6 RNA polymerase subunit
Length: 99 amino acids
Theoretical weight: 11.53 KDa
Source organism: Thermus thermophilus HB8
Expression system: Thermus thermophilus
UniProt:
- Canonical: Q8RQE7 (Residues: 1-99; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
Structure domains: Eukaryotic RPB6 RNA polymerase subunit
