We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

4h0r

X-ray diffraction
2.3Å resolution

Crystal structure of thymidylate synthase from Corynebacterium glutamicum

Released:
Model geometry
Fit model/data
Entry authors: Chang CM, Wang WC

Function and Biology Details

Reaction catalysed:
dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate +dTMP.
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185655 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidylate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.26 KDa
Source organism: Corynebacterium glutamicum ATCC 13032
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NS38 (Residues: 1-266; Coverage: 100%)
Gene names: Cgl0844, cg0966, thyA
Sequence domains: Thymidylate synthase
Structure domains: Thymidylate synthase/dCMP hydroxymethylase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P21
Unit cell:
a: 52.464Å b: 67.22Å c: 78.12Å
α: 90° β: 91.57° γ: 90°
R-values:
R R work R free
0.186 0.183 0.231
Expression system: Escherichia coli