› 4h7w

X-ray diffraction
1.1Å resolution

Crystal Structure of Human C16orf57

Released:
DOI: 10.2210/pdb4h7w/pdb
PDB entry 4h7w coloured by chain, front view.
PDB entry 4h7w coloured by chain, side view.
PDB entry 4h7w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia.
Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ, Jin L, Packman LC, Shlien A, Campbell P, Kirwan M, Dokal I, Warren AJ
Blood 121 1028-38 (2013)
PMID: 23190533

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U6 snRNA phosphodiesterase 1 Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 22.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BQ65 (Residues: 73-265; Coverage: 73%)
Gene names: C16orf57, Mpn1, USB1
Sequence domains: Uncharacterised conserved protein
Structure domains: Cyclic phosphodiesterase

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 43.247Å b: 51.07Å c: 48.013Å
α: 90° β: 107.44° γ: 90°
R-values:
R R work R free
0.133 0.132 0.154
Expression system: Escherichia coli

Quick links

Citations

13 review citations

The life of U6 small nuclear RNA, from cradle to grave.
Didychuk et al. (2018)
12 more

4 mentions without citation

The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation.
Huynh et al. (2023)
3 more