› 4hb1

X-ray diffraction
2.9Å resolution

A DESIGNED FOUR HELIX BUNDLE PROTEIN.

Released:
DOI: 10.2210/pdb4hb1/pdb
PDB entry 4hb1 coloured by chain, front view.
PDB entry 4hb1 coloured by chain, side view.
PDB entry 4hb1 coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
A designed four helix bundle protein with native-like structure.
Schafmeister CE, LaPorte SL, Miercke LJ, Stroud RM
Nat Struct Biol 4 1039-46 (1997)
PMID: 9406555

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DHP1 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 11.82 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Immunoglobulin FC, subunit C

Ligands and Environments

1 bound ligand:
Ligand UNX 2 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL
Spacegroup: P6422
Unit cell:
a: 51.9Å b: 51.9Å c: 61Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.234 0.284
Expression system: Escherichia coli

Quick links

Citations

15 review citations

De novo design and structural characterization of proteins and metalloproteins.
DeGrado et al. (1999)
14 more

6 mentions without citation

De novo protein design, a retrospective.
Korendovych et al. (2020)
5 more