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› 4hb7

X-ray diffraction
1.95Å resolution

The Structure of Dihydropteroate Synthase from Staphylococcus aureus subsp. aureus Mu50.

Released:
DOI: 10.2210/pdb4hb7/pdb
Model geometry
Fit model/data
PDB entry 4hb7 coloured by chain, front view.
PDB entry 4hb7 coloured by chain, side view.
PDB entry 4hb7 coloured by chain, top view.
Source organism: Staphylococcus aureus subsp. aureus Mu50
Entry authors: Cuff ME, Holowicki J, Jedrzejczak R, Terwilliger TC, Rubin EJ, Guinn K, Baker D, Ioerger TR, Sacchettini JC, Joachimiak A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)

Function and Biology Details

Reaction catalysed: 
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropteroate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 270 amino acids
Theoretical weight: 29.84 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P64141 (Residues: 1-267; Coverage: 100%)
Gene names: SAV0514, folP
Sequence domains: Pterin binding enzyme
Structure domains: Dihydropteroate synthase-like

Ligands and Environments

1 bound ligand:
Ligand EDO 7 x EDO
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 90.584Å b: 77.301Å c: 90.546Å
α: 90° β: 99.75° γ: 90°
R-values:
R R work R free
0.164 0.162 0.206
Expression system: Escherichia coli BL21(DE3)

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