› 4hbc

X-ray diffraction
1.54Å resolution

Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers

Released:
DOI: 10.2210/pdb4hbc/pdb
PDB entry 4hbc coloured by chain, front view.
PDB entry 4hbc coloured by chain, side view.
PDB entry 4hbc coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers.
Arai H, Glabe C, Luecke H
Biochim Biophys Acta 1820 1908-14 (2012)
PMID: 22940003

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213486 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Antigen Binding Fragment, Immunoglobulin IgG - Heavy Chain Chain: H
Molecule details ›
Chain: H
Length: 215 amino acids
Theoretical weight: 22.68 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Antigen Binding Fragment, Immunoglobulin IgG - Light Chain Chain: L
Molecule details ›
Chain: L
Length: 213 amino acids
Theoretical weight: 22.69 KDa
Source organism: Oryctolagus cuniculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: C2
Unit cell:
a: 132.934Å b: 42.184Å c: 86.179Å
α: 90° β: 114.93° γ: 90°
R-values:
R R work R free
0.2 0.197 0.259
Expression system: Homo sapiens

Quick links

Citations

2 review citations

Camelid single-domain antibody fragments: Uses and prospects to investigate protein misfolding and aggregation, and to treat diseases associated with these phenomena.
Pain et al. (2015)
1 more

6 mentions without citation

Leporid immunoglobulin G shows evidence of strong selective pressure on the hinge and CH3 domains.
Pinheiro et al. (2014)
5 more