› 4hbp

X-ray diffraction
2.91Å resolution

Crystal Structure of FAAH in complex with inhibitor

Released:
DOI: 10.2210/pdb4hbp/pdb
PDB entry 4hbp coloured by chain, front view.
PDB entry 4hbp coloured by chain, side view.
PDB entry 4hbp coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Kono M, Matsumoto T, Kawamura T, Nishimura A, Kiyota Y, Oki H, Miyazaki J, Igaki S, Behnke CA, Shimojo M, Kori M
Bioorg Med Chem 21 28-41 (2013)
PMID: 23218778

Function and Biology Details

Reaction catalysed: 
Anandamide + H(2)O = arachidonic acid + ethanolamine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty-acid amide hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 550 amino acids
Theoretical weight: 60.53 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P97612 (Residues: 30-579; Coverage: 95%)
Gene names: Faah, Faah1
Sequence domains: Amidase
Structure domains: Amidase signature (AS) domain

Ligands and Environments

1 bound ligand:
Ligand 17J 2 x 17J
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3221
Unit cell:
a: 103.92Å b: 103.92Å c: 251.965Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.226 0.223 0.273
Expression system: Escherichia coli

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Citations

13 citation in other articles

Synthesis, in vitro anticancer and antimycobacterial evaluation of new 5-(2,5-dimethoxyphenyl)-1,3,4-thiadiazole-2-amino derivatives.
Polkam et al. (2015)
12 more

2 mentions without citation

Stability and Removal of Benzophenone-Type UV Filters from Water Matrices by Advanced Oxidation Processes.
Imamović et al. (2022)
1 more