› 4hoq

X-ray diffraction
2.07Å resolution

Crystal Structure of Full-Length Human IFIT5

Released:
DOI: 10.2210/pdb4hoq/pdb
PDB entry 4hoq coloured by chain, front view.
PDB entry 4hoq coloured by chain, side view.
PDB entry 4hoq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B
Nature 494 60-4 (2013)
PMID: 23334420

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171638 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced protein with tetratricopeptide repeats 5 Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 56.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13325 (Residues: 1-482; Coverage: 100%)
Gene names: IFIT5, ISG58, RI58
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 7 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 64.15Å b: 71.428Å c: 117.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.165 0.213
Expression system: Escherichia coli

Quick links

Citations

40 review citations

Newly described pattern recognition receptors team up against intracellular pathogens.
Broz et al. (2013)
39 more

5 mentions without citation

When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.
Leung et al. (2016)
4 more