› 4hos

X-ray diffraction
2Å resolution

Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine

Released:
DOI: 10.2210/pdb4hos/pdb
PDB entry 4hos coloured by chain, front view.
PDB entry 4hos coloured by chain, side view.
PDB entry 4hos coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
Abbas YM, Pichlmair A, Górna MW, Superti-Furga G, Nagar B
Nature 494 60-4 (2013)
PMID: 23334420

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171640 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Interferon-induced protein with tetratricopeptide repeats 5 Chain: A
Molecule details ›
Chain: A
Length: 482 amino acids
Theoretical weight: 55.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13325 (Residues: 1-482; Coverage: 100%)
Gene names: IFIT5, ISG58, RI58
Sequence domains:
Structure domains: Tetratricopeptide repeat domain
RNA (5'-R(*(UTP)P*UP*UP*U)-3') Chain: X
Molecule details ›
Chain: X
Length: 4 nucleotides
Theoretical weight: 1.34 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 54.475Å b: 84.939Å c: 60.928Å
α: 90° β: 106.75° γ: 90°
R-values:
R R work R free
0.177 0.175 0.207
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

41 review citations

mRNA capping: biological functions and applications.
Ramanathan et al. (2016)
40 more

4 mentions without citation

IFITs: Emerging Roles as Key Anti-Viral Proteins.
Vladimer et al. (2014)
3 more