› 4hp9

X-ray diffraction
2.12Å resolution

Crystal structure of the N-terminal truncated PAS domain from the hERG potassium channel

Released:
DOI: 10.2210/pdb4hp9/pdb
PDB entry 4hp9 coloured by chain, front view.
PDB entry 4hp9 coloured by chain, side view.
PDB entry 4hp9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural properties of PAS domains from the KCNH potassium channels.
Adaixo R, Harley CA, Castro-Rodrigues AF, Morais-Cabral JH
PLoS One 8 e59265 (2013)
PMID: 23555008

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium voltage-gated channel subfamily H member 2 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12809 (Residues: 10-135; Coverage: 11%)
Gene names: ERG, ERG1, HERG, KCNH2
Sequence domains: PAS domain
Structure domains: PAS domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P4232
Unit cell:
a: 89.528Å b: 89.528Å c: 89.528Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.194 0.238
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Kv10.1 K(+) channel: from physiology to cancer.
Ouadid-Ahidouch et al. (2016)
11 more

7 mentions without citation

Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.
Anderson et al. (2014)
6 more