› 4hpf

X-ray diffraction
3.4Å resolution

Structure of the human SLO3 gating ring

Released:
DOI: 10.2210/pdb4hpf/pdb
PDB entry 4hpf coloured by chain, front view.
PDB entry 4hpf coloured by chain, side view.
PDB entry 4hpf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Leonetti MD, Yuan P, Hsiung Y, Mackinnon R
Proc Natl Acad Sci U S A 109 19274-9 (2012)
PMID: 23129643

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily U member 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 722 amino acids
Theoretical weight: 81.22 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: A8MYU2 (Residues: 330-1062; Coverage: 62%)
Gene names: KCNMA3, KCNMC1, KCNU1, SLO3
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: I222
Unit cell:
a: 124.54Å b: 157.94Å c: 249.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.247 0.267
Expression system: Spodoptera frugiperda

Quick links

Citations

12 review citations

International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.
Kaczmarek et al. (2017)
11 more

3 mentions without citation

Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Leonetti et al. (2012)
2 more