› 4hu2

X-ray diffraction
1.46Å resolution

Crystal structure of LdtMt2, a L,D-transpeptidase from Mycobacterium tuberculosis: domain A and B

Released:
DOI: 10.2210/pdb4hu2/pdb
PDB entry 4hu2 coloured by chain, front view.
PDB entry 4hu2 coloured by chain, side view.
PDB entry 4hu2 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure of LdtMt2, an L,D-transpeptidase from Mycobacterium tuberculosis.
Böth D, Steiner EM, Stadler D, Lindqvist Y, Schnell R, Schneider G
Acta Crystallogr D Biol Crystallogr 69 432-41 (2013)
PMID: 23519418

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129428 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L,D-transpeptidase 2 Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 21.05 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O53223 (Residues: 55-250; Coverage: 52%)
Gene names: MT2594, V735_02606, ldtB
Sequence domains: Bacterial Ig domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2
Unit cell:
a: 114.433Å b: 27.638Å c: 67.99Å
α: 90° β: 114.14° γ: 90°
R-values:
R R work R free
0.165 0.162 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Peptidoglycan remodeling by the coordinated action of multispecific enzymes.
Alvarez et al. (2014)
2 more

5 mentions without citation

Loss of a Functionally and Structurally Distinct ld-Transpeptidase, LdtMt5, Compromises Cell Wall Integrity in Mycobacterium tuberculosis.
Brammer Basta et al. (2015)
4 more