› 4hvm

X-ray diffraction
2.7Å resolution

Crystal structure of tallysomycin biosynthesis protein TlmII

Released:
DOI: 10.2210/pdb4hvm/pdb
PDB entry 4hvm coloured by chain, front view.
PDB entry 4hvm coloured by chain, side view.
PDB entry 4hvm coloured by chain, top view.
Source organism: Streptoalloteichus hindustanus
Entry authors: Chang C, Bigelow L, Bearden J, Babnigg G, Bingman CA, Yennamalli R, Lohman J, Ma M, Shen B, Phillips Jr GN, Joachimiak A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-107383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Condensation domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 493 amino acids
Theoretical weight: 54.12 KDa
Source organism: Streptoalloteichus hindustanus
Expression system: Escherichia coli
UniProt:
  • Canonical: A4KUC0 (Residues: 1-490; Coverage: 100%)
Gene name: tlmII
Sequence domains: Condensation domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
1 modified residue:
Ligand MSE 32 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 123.799Å b: 128.015Å c: 129.307Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.232
Expression system: Escherichia coli

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