› 4hwe

X-ray diffraction
2.43Å resolution

Crystal structure of ectodomain 3 of the IL-13 receptor alpha1 in complex with a human neutralizing monoclonal antibody fragment

Released:
DOI: 10.2210/pdb4hwe/pdb
PDB entry 4hwe coloured by chain, front view.
PDB entry 4hwe coloured by chain, side view.
PDB entry 4hwe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1.
Redpath NT, Xu Y, Wilson NJ, Fabri LJ, Baca M, Andrews AE, Braley H, Lu P, Ireland C, Ernst RE, Woods A, Forrest G, An Z, Zaller DM, Strohl WR, Luo CS, Czabotar PE, Garrett TP, Hilton DJ, Nash AD, Zhang JG, Nicola NA
Biochem J 451 165-75 (2013)
PMID: 23384096

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213496 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fab heavy chain Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Fab light chain Chain: L
Molecule details ›
Chain: L
Length: 211 amino acids
Theoretical weight: 23.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand GOL 10 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: I422
Unit cell:
a: 121.364Å b: 121.364Å c: 152.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.178 0.175 0.223
Expression system: Escherichia coli

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Citations

1 review citation

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy.
Matsumoto et al. (2017)
5 other articles