› 4hy7

X-ray diffraction
1.2Å resolution

Structural and biochemical characterization of a cytosolic wheat cyclophilin TaCypA-1

Released:
DOI: 10.2210/pdb4hy7/pdb
PDB entry 4hy7 coloured by chain, front view.
PDB entry 4hy7 coloured by chain, side view.
PDB entry 4hy7 coloured by chain, top view.
Source organisms:
Primary publication:
Structural and biochemical characterization of the cytosolic wheat cyclophilin TaCypA-1.
Sekhon SS, Kaur H, Dutta T, Singh K, Kumari S, Kang S, Park SG, Park BC, Jeong DG, Pareek A, Woo EJ, Singh P, Yoon TS
Acta Crystallogr D Biol Crystallogr 69 555-63 (2013)
PMID: 23519664

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164561 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase Chain: A
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 18.42 KDa
Source organism: Triticum aestivum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q93W25 (Residues: 1-171; Coverage: 100%)
Gene names: CFC21_082064, CFC21_091348, CFC21_091349, CyP1, CyP3, TaBWCyp A-1
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
Cyclosporin A Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.22 KDa
Source organism: Tolypocladium inflatum

Ligands and Environments

No bound ligands
6 modified residues:
Ligand DAL 1 x DAL
Ligand MLE 4 x MLE
Ligand MVA 1 x MVA
Ligand BMT 1 x BMT
Ligand ABA 1 x ABA
Ligand SAR 1 x SAR

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 37.914Å b: 49.847Å c: 78.976Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.204
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles.
Singh et al. (2020)
1 more

4 mentions without citation

Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3.
Kaur et al. (2015)
3 more