› 4hzc

X-ray diffraction
1.97Å resolution

Crystal structure of Serine acetyltransferase from Brucella abortus strain S19

Released:
DOI: 10.2210/pdb4hzc/pdb
Model geometry
Fit model/data
PDB entry 4hzc coloured by chain, front view.
PDB entry 4hzc coloured by chain, side view.
PDB entry 4hzc coloured by chain, top view.
Source organism: Brucella abortus S19
Primary publication:
Crystal structure of serine acetyl transferase from Brucella abortus and its complex with coenzyme A.
Kumar S, Kumar N, Alam N, Gourinath S
Biochim Biophys Acta 1844 1741-8 (2014)
PMID: 25058332

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine acetyltransferase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 281 amino acids
Theoretical weight: 30.8 KDa
Source organism: Brucella abortus S19
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0F6AR69 (Residues: 1-274; Coverage: 100%)
Gene name: BAbS19_I11940
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand TRS 5 x TRS
Ligand MG 9 x MG
Ligand CL 1 x CL
Ligand 15P 1 x 15P
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21
Unit cell:
a: 73.697Å b: 256.774Å c: 82.285Å
α: 90° β: 91.2° γ: 90°
R-values:
R R work R free
0.189 0.187 0.239
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens.
Hicks et al. (2022)
5 other articles

1 mention without citation

New insights into the structure and function of an emerging drug target CysE.
Verma et al. (2021)