› 4hzr

X-ray diffraction
1.31Å resolution

Crystal structure of Ack1 kinase domain

Released:
DOI: 10.2210/pdb4hzr/pdb
PDB entry 4hzr coloured by chain, front view.
PDB entry 4hzr coloured by chain, side view.
PDB entry 4hzr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ack1: activation and regulation by allostery.
Gajiwala KS, Maegley K, Ferre R, He YA, Yu X
PLoS One 8 e53994 (2013)
PMID: 23342057

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activated CDC42 kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 277 amino acids
Theoretical weight: 31.58 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q07912 (Residues: 115-389; Coverage: 27%)
Gene names: ACK1, TNK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand EDO 2 x EDO
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 71.057Å b: 42.34Å c: 92.59Å
α: 90° β: 98.6° γ: 90°
R-values:
R R work R free
0.197 0.196 0.209
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Mahajan et al. (2015)
4 more

7 mentions without citation

Progress in the therapeutic inhibition of Cdc42 signalling.
Murphy et al. (2021)
6 more