Function and Biology Details
Reaction catalysed:
(R)-mevalonate + CoA + 2 NAD(+) = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
- Hydroxymethylglutaryl-CoA reductase, class I/II
- Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
- Hydroxymethylglutaryl-CoA reductase, bacterial-type
- Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
- Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (preferred)
PDBe Complex ID:
PDB-CPX-146717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Molecule details ›
Chains: A, B
Length: 428 amino acids
Theoretical weight: 45.64 KDa
Source organism: Pseudomonas mevalonii
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
Length: 428 amino acids
Theoretical weight: 45.64 KDa
Source organism: Pseudomonas mevalonii
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P13702 (Residues: 1-428; Coverage: 100%)
Sequence domains: Hydroxymethylglutaryl-coenzyme A reductase
Structure domains:
